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Science and Medicine

2005, v. 10, n. 3

  • Página 143
    Autor/es: Howard M. Spiro
    Título: Tolling the Truth (part II) [Optimist]
    Resumen: The current climate of opinion leaves no room for dissension from the idea that physicians must always tell the truth. Given the current legal consequences of such veracity, my title ¿Tolling the Truth¿ is intended to call up an image of bells doleful at

  • Página 146
    Autor/es: W. Garrett Nichols
    Título: Chemokine Receptors in Anti-HIV Therapy [Drug Discovery]
    Resumen: An estimated 3 to 9% of the population is affected by some degree of vocal fold scarring. In June 2002, a new research initiative on vocal fold restoration was announced, with the goal being to reestablish normal vibratory characteristics to scarred vocal

  • Página 149
    Autor/es: R.J. Clifton; et al.
    Título: Vocal Fold Bioengineering [Tissue Engineering]
    Resumen: An estimated 3 to 9% of the population is affected by some degree of vocal fold scarring. In June 2002, a new research initiative on vocal fold restoration was announced, with the goal being to reestablish normal vibratory characteristics to scarred vocal

  • Página 154
    Autor/es: Massimo Zeviani; Eleonora Lamantea
    Título: Genetic Disorders of the Mitochondrial OXPHOS System
    Resumen: The principal function of mitochondria is to produce energy, which it achieves via the electron transport chain and oxidative phosphorylation (OXPHOS). The OXPHOS system consists of five multiprotein complexes, the individual subunits of which are encoded

  • Página 168
    Autor/es: Gert Van Assche; Séverine Vermeire; Paul Rutgeerts
    Título: Anti-Adhesion Molecule Therapy for Inflammatory Bowel Disease
    Resumen: Within the intestinal mucosa, adhesion molecules are involved in local lymphocyte stimulation and antigen presentation, as well as in the regulation of leukocyte influx. In inflammation, many adhesion molecules are upregulated, but a4-integrins likely hol

  • Página 180
    Autor/es: M. Bokulich
    Título: Chronic Inflammation, NF-kB, and Cancer
    Resumen: The inflammatory microenvironment is characterized by the presence of activated macrophages and other immune cell types, which secrete a host of proinflammatory factors, such as cytokines, chemokines, and proteases. In chronic inflammation, this unabated

  • Página 194
    Autor/es: Gerard D. Wright, Sherry S. Lamb
    Título: Natural Products: Reassessing Biosynthetic Strategies
    Resumen: Natural products represent a rich source of highly potent, bioactive compounds that have long been prized by drug discoverers. Bioactivity is a hallmark of many natural products, as are the chemical strategies of their assembly, chirality, and accessory f